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Literature Study of OxyR

OxyR, a positive regulator of hydrogenle genes in E. coli. The OxyR transcription factor regulates the H₂O₂ response of E. coli.

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H₂O₂ oxidizes OxyR Cys199 to an R-SOH that reacts with Cys208 in an intramolecular disulphide bond.

Structure of the OxyR Regulatory Domain
(A) Reduced Form: Inactive
(B) Oxidized Form: Activated by ROS

_{Reference: D'Autréaux, B., & Toledano, M. B. (October 01, 2007). ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nature Reviews Molecular Cell Biology, 8, 10, 813-824.}

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